Chapter

± 0.83%; cluster 8: 4.20 ± 2.36% vs. 3.78 ± 2.44%; cluster 9: 11.40 ± 7.73% vs. 3.39 ± 2.76%; Fig.

From Covid research by Sambif

Concepts

  1. NK Clusters

    "While these clusters shared high Siglec-9 expression, they displayed distinct activating receptor profiles: NKp30 was highly expressed in clusters 2 and 8, whereas DNAM-1 (CD226) and NKp46 were eleva

  2. Responder Profiles

    "Our analysis revealed distinct immunological architectures that differentiate fast responders from slow responders to SARS-CoV-2 infection. In fast responders, the immune landscape is dominated by cy

  3. NK Regulation

    "Consistent with this, CD107a/b⁺ NK cells exhibited higher Siglec-9 expression compared with CD107a/b⁻ cells. Siglec-9 is a member of the glyco-immune checkpoint family and has been implicated in the

  4. ADCC Protection

    "Neutralizing activity was not upregulated in slow responders, despite the fact that prolonged antigen exposure can enhance antibody affinity and neutralization. Neutralization titers in COVID-19 pati

± 0.83%; cluster 8: 4.20 ± 2.36% vs. 3.78 ± 2.44%; cluster 9: 11.40 ± 7.73% vs. 3.39 ± 2.76%; Fig. | Covid research | Bifalgorithm | Bifalgorithm