Chapter

ARTICLE IN PRESS

From Covid research by Sambif

Concepts

1. Bulk Transcriptomics

   "To elucidate the protective mechanism of an ADCC mAb against SARS-CoV-2 infection, we employed transcriptome analysis on K18-hACE2 transgenic mice with or without 5SB12 mAb pretreatment and SARS-CoV-

2. Gene Enrichment

   "To address the putative protective mechanisms of the ADCC mAb 5SB12 against SARS-CoV-2 infection, functional enrichment analysis was conducted, particularly between the infected −/+ and +/+ samples.

3. Spatial Profiling

   "We next employed spatial transcriptomics analysis on the four treatment groups, with duplicates for each group, to further dissect whether immune cell types, particularly NK cells, were enriched in t