Chapter

Drug Development

From Future of Cancer Science | AACR Cancer Progress Report 2025 by Sambif

Concepts

1. Drug Development

   "By enabling researchers to systematically investigate the molecular pathways that drive cancer growth, resistance, and immune evasion, CRISPR is contributing to advances in drug development strategie

2. Immune Evasion

   "Recently, CRISPR screening has been used to identify novel immune-related targets that boost the effectiveness of chimeric antigen receptor (CAR) T-cell therapy and reveal mechanisms of immune evasio

3. Synthetic Lethality

   "Researchers have also developed a CRISPR screening platform to identify synthetic lethal interactions, which occur when two otherwise tolerated gene changes occur simultaneously and lead to cell deat