Bifalgorithm post · Human Nutrition · Protein Digestion and Absorption

Amino Absorption

Amino Absorption (Human Nutrition · Protein Digestion and Absorption) — "The stomach empties the chyme containing the broken down egg pieces into the small int…

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  • Digestion, absorption, and fate of dietary proteins
  • The stomach empties chyme containing broken-down egg pieces into the small intestine, where most protein digestion occurs.
  • The pancreas secretes digestive juice containing enzymes that further break down protein fragments.
  • The major pancreatic protein-digesting enzymes are chymotrypsin and trypsin.
  • Cells lining the small intestine release enzymes that break smaller fragments into individual amino acids.
  • Muscle contractions mix and propel digested proteins toward absorption sites.
  • In the lower small intestine, individual amino acids move from the intestinal lumen into the blood.
  • Amino acid transport requires special transport proteins and ATP.
  • After entering the blood, amino acids are transported to the liver.
  • The liver is the checkpoint for amino acid distribution and further breakdown, which is minimal.
  • Further amino acid catabolism releases nitrogen-containing ammonia.
  • Because ammonia is toxic, the liver transforms it into urea.
  • Urea contains two nitrogens and is highly soluble in water, making it suitable for transporting excess nitrogen.
  • Urea is transported to the kidney and excreted in the urine.
  • More than 90 percent of ingested protein remains at the amino acid level because amino acids are building blocks for other proteins.
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Amino Absorption

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Human Nutrition

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"The stomach empties the chyme containing the broken down egg pieces into the small intestine, where the majority of protein digestion occurs. The pancreas secretes digestive juice that contains more enzymes that further break down the protein fragments. The two major pancreatic enzymes that digest proteins are chymotrypsin and trypsin. The cells that line the small intestine release additional enzymes that finally break apart the smaller protein fragments into the individual amino acids. The muscle contractions of the small intestine mix and propel the digested proteins to the absorption sites. In the lower parts of the small intestine, the amino acids are transported from the intestinal lumen through the intestinal cells to the blood. This movement of individual amino acids requires special transport proteins and the cellular energy molecule, adenosine triphosphate (ATP). Once the amino acids are in the blood, they are transported to the liver. As with other macronutrients, the liver is the checkpoint for amino acid distribution and any further breakdown of amino acids, which is very minimal. Recall that amino acids contain nitrogen, so further catabolism of amino acids releases nitrogen-containing ammonia. Because ammonia is toxic, the liver transforms it into urea, which is then transported to the kidney and excreted in the urine. Urea is a molecule that contains two nitrogens and is highly soluble in water. This makes it a good choice for transporting excess nitrogen out of the body. Because amino acids are building blocks that the body reserves in order to synthesize other proteins, more than 90 percent of the protein ingested does not get broken down further than the amino acid monomers."

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