Bifalgorithm post · Human Nutrition · Fat-Soluble Vitamins
Toxicity Sources
Toxicity Sources (Human Nutrition · Fat-Soluble Vitamins) — "Vitamin A toxicity, or hypervitaminosis A, is rare. Typically it requires you to ingest ten times…
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- Vitamin A: sources, requirements, conversions, and toxicity
- Vitamin A toxicity is rare and typically requires about ten times the RDA of preformed vitamin A from supplements over a substantial period.
- Some people may develop toxicity at lower doses.
- Signs include dry, itchy skin, loss of appetite, brain swelling, and joint pain.
- Severe toxicity may cause liver damage and coma.
- Vitamin A is essential during pregnancy, but excessive intake increases risk.
- Doses above 3,000 micrograms RAE or 10,000 IU per day have been linked to more birth defects.
- Pregnant women should verify that prenatal vitamin A intake remains below the UL.
- Dietary vitamin A comes from preformed vitamin A and carotenoids.
- Preformed vitamin A is abundant in animal-derived foods.
- Carotenoids are concentrated in vibrantly colored fruits, vegetables, and some oils.
- Some carotenoids are converted to retinol by intestinal and liver cells, but conversion may be minuscule.
- The RDA combines all vitamin A sources and expresses them as retinol activity equivalents (RAE).
- The body converts dietary vitamin A sources into retinol.
- One microgram of retinol equals 12 micrograms of beta-carotene or 24 micrograms of alpha-carotene or beta-cryptoxanthin.
- Food and supplement labels also use IU conversion factors that differ by vitamin A form and source.
- The RDA supports growth, development, reproduction, vision, immunity, and liver stores lasting about four months.
- Infants: 0–6 months need 400 micrograms RAE daily with a 600 microgram UL; 7–12 months need 500 micrograms with the same UL.
- Children: ages 1–3 need 300 micrograms RAE with a 600 microgram UL; ages 4–8 need 400 micrograms with a 900 microgram UL; ages 9–13 need 600 micrograms with a 1,700 microgram UL.
- Adolescents: males 14–18 need 900 micrograms RAE and females need 700 micrograms; the UL is 2,800 micrograms for both.
- Adults over 19: males need 900 micrograms RAE and females need 700 micrograms; the UL is 3,000 micrograms for both.
- The liver is the richest animal source because it stores vitamin A.
- Per serving, beef liver provides 27,185 IU, chicken liver 12,325 IU, skim milk 500 IU, whole milk 249 IU, and cheddar cheese 284 IU.