Bifalgorithm post · Human Nutrition · Fat-Soluble Vitamins

Toxicity Sources

Toxicity Sources (Human Nutrition · Fat-Soluble Vitamins) — "Vitamin A toxicity, or hypervitaminosis A, is rare. Typically it requires you to ingest ten times…

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  • Vitamin A: sources, requirements, conversions, and toxicity
  • Vitamin A toxicity is rare and typically requires about ten times the RDA of preformed vitamin A from supplements over a substantial period.
  • Some people may develop toxicity at lower doses.
  • Signs include dry, itchy skin, loss of appetite, brain swelling, and joint pain.
  • Severe toxicity may cause liver damage and coma.
  • Vitamin A is essential during pregnancy, but excessive intake increases risk.
  • Doses above 3,000 micrograms RAE or 10,000 IU per day have been linked to more birth defects.
  • Pregnant women should verify that prenatal vitamin A intake remains below the UL.
  • Dietary vitamin A comes from preformed vitamin A and carotenoids.
  • Preformed vitamin A is abundant in animal-derived foods.
  • Carotenoids are concentrated in vibrantly colored fruits, vegetables, and some oils.
  • Some carotenoids are converted to retinol by intestinal and liver cells, but conversion may be minuscule.
  • The RDA combines all vitamin A sources and expresses them as retinol activity equivalents (RAE).
  • The body converts dietary vitamin A sources into retinol.
  • One microgram of retinol equals 12 micrograms of beta-carotene or 24 micrograms of alpha-carotene or beta-cryptoxanthin.
  • Food and supplement labels also use IU conversion factors that differ by vitamin A form and source.
  • The RDA supports growth, development, reproduction, vision, immunity, and liver stores lasting about four months.
  • Infants: 0–6 months need 400 micrograms RAE daily with a 600 microgram UL; 7–12 months need 500 micrograms with the same UL.
  • Children: ages 1–3 need 300 micrograms RAE with a 600 microgram UL; ages 4–8 need 400 micrograms with a 900 microgram UL; ages 9–13 need 600 micrograms with a 1,700 microgram UL.
  • Adolescents: males 14–18 need 900 micrograms RAE and females need 700 micrograms; the UL is 2,800 micrograms for both.
  • Adults over 19: males need 900 micrograms RAE and females need 700 micrograms; the UL is 3,000 micrograms for both.
  • The liver is the richest animal source because it stores vitamin A.
  • Per serving, beef liver provides 27,185 IU, chicken liver 12,325 IU, skim milk 500 IU, whole milk 249 IU, and cheddar cheese 284 IU.
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Toxicity Sources

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Human Nutrition

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"Vitamin A toxicity, or hypervitaminosis A, is rare. Typically it requires you to ingest ten times the RDA of preformed vitamin A in the form of supplements—it would be hard to consume such high levels from a regular diet—for a substantial amount of time, although some people may be more susceptible to vitamin A toxicity at lower doses. The signs and symptoms of vitamin A toxicity include dry, itchy skin, loss of appetite, swelling of the brain, and joint pain. In severe cases, vitamin A toxicity may cause liver damage and coma. Vitamin A is essential during pregnancy, but doses above 3,000 micrograms per day, or 10,000 international units, have been linked to an increased incidence of birth defects. Pregnant women should check the amount of vitamin A contained in any prenatal or pregnancy multivitamin she is taking to assure the amount is below the UL. There is more than one source of vitamin A in the diet. There is preformed vitamin A, which is abundant in many animal-derived foods, and there are carotenoids, which are found in high concentrations in vibrantly colored fruits and vegetables and some oils. Some carotenoids are converted to retinol in the body by intestinal cells and liver cells. However, only minuscule amounts of certain carotenoids are converted to retinol, meaning fruits and vegetables are not necessarily good sources of vitamin A. The RDA for vitamin A includes all sources of vitamin A and is given in micrograms of retinol activity equivalents (RAE) to take into account the many different forms it is available in. The human body converts all dietary sources of vitamin A into retinol. Therefore, 1 microgram of retinol is equivalent to 12 micrograms of beta-carotene, and 24 micrograms of alpha-carotene or beta-cryptoxanthin. For example, 12 micrograms of fruit- or vegetable-based beta-carotene will yield 1 microgram of retinol. Current vitamin A listings in food and on supplement labels use international units (IUs): 1 IU retinol equals 0.3 micrograms RAE; 1 IU beta-carotene from dietary supplements equals 0.15 micrograms RAE; 1 IU beta-carotene from food equals 0.05 micrograms RAE; and 1 IU alpha-carotene or beta-cryptoxanthin equals 0.025 micrograms RAE. The RDA for vitamin A is considered sufficient to support growth and development, reproduction, vision, and immune system function while maintaining adequate stores, which are good for four months, in the liver. The RDA and UL are as follows: infants 0–6 months, 400 micrograms RAE per day as adequate intake and a 600 microgram UL; infants 7–12 months, 500 micrograms as adequate intake and a 600 microgram UL; children 1–3 years, 300 micrograms RAE and a 600 microgram UL; children 4–8 years, 400 micrograms and a 900 microgram UL; children 9–13 years, 600 micrograms and a 1,700 microgram UL; adolescent males 14–18 years, 900 micrograms and a 2,800 microgram UL; adolescent females 14–18 years, 700 micrograms and a 2,800 microgram UL; adult males over 19 years, 900 micrograms and a 3,000 microgram UL; and adult females over 19 years, 700 micrograms and a 3,000 microgram UL. Preformed vitamin A is found only in foods from animals, with the liver being the richest source because that is where vitamin A is stored. Beef liver provides 27,185 IU per 3-ounce serving, chicken liver provides 12,325 IU per 3-ounce serving, skim milk provides 500 IU per cup, whole milk provides 249 IU per cup, and cheddar cheese provides 284 IU per ounce."

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