Bifalgorithm post · Nature.com · Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism

Myeloid Agonist

Myeloid Agonist (Nature.com · Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism) — "A tetravalent nanobody-based myeloid-selective IL…

Ideas in this flowchart

  • Tetravalent nanobody-based myeloid-selective IL-10 receptor agonist
  • The agonist is designed using tetravalent nanobody-based receptor targeting
  • It recapitulates IL-10’s potent suppression of myeloid cells
  • Monocytes are strongly suppressed
  • Macrophages are strongly suppressed
  • Dendritic cells are strongly suppressed
  • The agonist avoids stimulation of T cells
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Myeloid Agonist

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Nature.com

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"A tetravalent nanobody-based myeloid-selective IL-10 receptor agonist recapitulates IL-10’s potent suppression of monocytes, macrophages and dendritic cells while avoiding stimulation of T cells."

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