"CRISPR gene editing has rapidly evolved into one of the most transformative tools in basic research. The ability of CRISPR systems to precisely modify genes in living cells has made it possible for researchers to model human diseases and uncover the genetic underpinnings of complex biological processes with unprecedented speed and accuracy.\n\nIn a recent study, researchers used base and prime editors to scan tens of thousands of mutations in the EGFR gene, a gene frequently mutated in lung cancer, revealing previously unknown variants that drive tumor growth or treatment resistance (1067)Belli O, et al. (2024) Nat Biotechnol.. This approach not only generated new insights into the genetic drivers of cancer but also demonstrated how precision editing can inform treatment decisions and accelerate the development of personalized therapies."