Ideas in this flowchart

• Advanced delivery systems are being developed to send CRISPR directly to tumors.
• Nanoparticle-based systems are a major approach for targeted CRISPR delivery.
• Some nanoparticles cross the blood–brain barrier and deliver CRISPR to glioblastoma cells.
• The blood–brain barrier is a protective layer of tightly packed cells that blocks harmful substances from reaching the brain.
• The gene editing is activated only within glioblastoma tumor cells.
• This approach enables selective gene editing within brain tumors.
• The glioblastoma nanoparticle system was reported by Li Q et al. in 2025.
• An EGFR-targeted nanoparticle delivers CRISPR to head and neck cancers.
• The EGFR-targeted system caused complete disappearance of tumors in some animal models.
• The head and neck cancer nanoparticle system was reported by Masarwy R et al. in 2025.