Ideas in this flowchart

• OGTT glucose, body-size measures, and insulin requirements show significant but limited predictive relationships
• Models 1 and 2 examined the initial insulin dose required to achieve the target
• OGTT fasting glucose was significantly associated with the initial insulin dose requirement
• Pregnancy weight was included in model 1 as an associated variable
• BMI was included in model 2 as an associated variable
• The performance of the initial-dose models was limited, as shown in table 3
• Models 3 and 4 predicted maximum insulin dose requirement
• Similar associations were observed for maximum insulin dose requirement
• The maximum-dose models performed even less well than the initial-dose models
• Models 5 to 8 compared variable association strength using standardized variables
• OGTT fasting glucose was the strongest predictor of initial insulin dose requirement
• OGTT fasting glucose, BMI, and pre-pregnancy weight had similar associations with maximum insulin dose requirement
• Sensitivity analyses adjusted the models for metformin use
• Adjustment for metformin did not substantially alter the relationships between OGTT glucose, BMI, and insulin requirements
• Correlations between fasting and 120-minute OGTT glucose and initial and peak insulin requirements are shown in supplemental figures S2–S5