Ideas in this flowchart

• Key strength of the study: using real-world clinical data to characterize insulin requirements during pregnancy
• The data came from women with GDM using a rapid insulin titration protocol
• The protocol acted like a homeostatic mechanism to adjust basal insulin doses to individual requirements
• This created a unique dataset for analyzing insulin requirements throughout pregnancy
• Small-scale data collection enabled high-fidelity capture of serial measurements
• The captured data included fasting glucose measurements and insulin dose adjustments
• The longitudinal data enabled evaluation of gestational insulin requirements over time
• This evaluation is not currently possible using large routinely collected datasets in the UK