Ideas in this flowchart

• ADCC-mediating antibodies recruit NK subsets to support effective pulmonary viral clearance.
• Spatial transcriptomic analysis examined mice treated with ADCC-mediating antibodies.
• Low expression of cytolytic NK cell markers is linked to pulmonary viral clearance.
• NK cell cluster-associated gene pathways are linked to pulmonary viral clearance.
• Human peripheral NK cells activate pre-existing NK cell clusters when engaging the ADCC antibody.
• The recruited NK subsets have low baseline cytolytic signatures.
• Recruitment of these NK subsets facilitates effective viral clearance.