Bifalgorithm post · Latest research · Assessment of functional status

Primary Analysis

Primary Analysis (Latest research · Assessment of functional status) — "For primary analyses, PCFS was dichotomized as none or negligible limitation (grades 0–…

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  • Primary analyses dichotomize PCFS into two functional-limitation categories.
  • PCFS is divided into none or negligible limitation versus at least slight functional limitation.
  • None or negligible limitation corresponds to PCFS grades 0–1.
  • At least slight functional limitation corresponds to PCFS grades ≥ 2.
  • The threshold is consistent with previous publications.
  • The threshold reflects clinically meaningful impairment in activities of daily living.
  • Higher PCFS grades contain sparse data.
  • The dichotomization allows stable model estimation.
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Primary Analysis

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"For primary analyses, PCFS was dichotomized as none or negligible limitation (grades 0–1) vs at least slight functional limitation (grades ≥ 2), consistent with previous publications14,15. This threshold reflects clinically meaningful impairment in activities of daily living and allows stable model estimation given sparse data in higher grades."

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