"Disease: AIDS/HIV infection. Pathogen: Human immunodeficiency virus (HIV). Signs and Symptoms: Flu-like symptoms during acute stage, followed by long period of clinical latency; final stage (AIDS) includes fever, weight loss, wasting syndrome, dementia, and opportunistic secondary infections leading to death. Transmission: Contact with body fluids (e.g., sexual contact, use of contaminated needles). Diagnostic Tests: Serological tests for antibodies and/or HIV antigens; nucleic acid test (NAT) for presence of virus. Antimicrobial Drugs: Antiretroviral therapy (ART) using various combinations of drugs.\n\nDisease: Burkitt lymphoma. Pathogen: Epstein-Barr virus (human herpesvirus-4 [HHV-4]). Signs and Symptoms: Rapid formation of malignant B-cell tumors, oral hairy leukoplakia; fatal if not promptly treated. Transmission: Contact with body fluids (e.g., saliva, blood, semen); primarily affects patients immunocompromised by HIV or malaria. Diagnostic Tests: CT scans, tumor biopsy. Antimicrobial Drugs: Intensive alternating chemotherapy regimen.\n\nDisease: Chikungunya fever. Pathogen: Chikungunya virus. Signs and Symptoms: Fever, rash, joint pain. Transmission: Transmitted between humans by Aedes aegypti and A. albopictus vectors. Diagnostic Tests: Viral culture, IFA, EIA, ELISA, PCR, RT-PCR. Antimicrobial Drugs: None.\n\nDisease: Cytomegalovirus infection. Pathogen: Cytomegalovirus (HHV-5). Signs and Symptoms: Usually asymptomatic but may cause non-Epstein-Barr mononucleosis in adults; may cause developmental issues in developing fetus; in transplant recipients, may cause fever, transplant rejection, death. Transmission: Contact with body fluids, blood transfusions, organ transplants; infected people can transmit virus to fetus transplacentally or to newborn in breastmilk, saliva. Diagnostic Tests: Histology, culture, EIA, IFA, PCR. Antimicrobial Drugs: Ganciclovir, valganciclovir, foscarnet, cidofovir.\n\nDisease: Dengue fever (breakbone fever). Pathogen: Dengue fever viruses 1–4. Signs and Symptoms: Fever, headache, extreme bone and joint pain, abdominal pain, vomiting, hemorrhaging; can be fatal. Transmission: Transmitted between humans by A. aegypti and A. albopictus vectors. Diagnostic Tests: Serologic testing, ELISA, and RT-PCR. Antimicrobial Drugs: None.\n\nDisease: Ebola virus disease (EVD). Pathogen: Ebola virus. Signs and Symptoms: Fever, headache, joint pain, diarrhea, vomiting, hemorrhaging in gastrointestinal tract, organ failure; often fatal. Transmission: Contact with body fluids (e.g., blood, saliva, sweat, urine, feces, vomit); highly contagious. Diagnostic Tests: ELISA, IgM ELISA, PCR, and virus isolation. Antimicrobial Drugs: None.\n\nDisease: Hantavirus pulmonary syndrome (HPS). Pathogen: Hantavirus. Signs and Symptoms: Initial flu-like symptoms followed by pulmonary edema and hypotension leading to pneumonia and shock; can be fatal. Transmission: Inhalation of dried feces, urine from infected mouse or rat. Diagnostic Tests: ELISA, Western blot, RIBA, RT-PCR. Antimicrobial Drugs: None.\n\nDisease: Hemorrhagic fever with renal syndrome. Pathogen: Hantavirus. Signs and Symptoms: Fever, headache, nausea, rash, or eye inflammation, followed by hemorrhaging and kidney failure; can be fatal. Transmission: Inhalation of dried feces, urine from infected mouse or rat. Diagnostic Tests: ELISA, Western blot, RIBA, RT-PCR. Antimicrobial Drugs: None.\n\nDisease: Infectious mononucleosis. Pathogen: Epstein-Barr virus (HHV-4), cytomegalovirus (HHV-5). Signs and Symptoms: Pharyngitis, fever, extreme fatigue; swelling of lymph nodes, spleen, and liver. Transmission: Contact with body fluids (e.g., saliva, blood, semen). Diagnostic Tests: Tests for antibodies to various EBV-associated antigens. Antimicrobial Drugs: None.\n\nDisease: Yellow fever. Pathogen: Yellow fever virus. Signs and Symptoms: Dizziness, fever, chills, headache, myalgia, nausea, vomiting, constipation, fatigue; moderate to severe cases may include jaundice, rash, mucosal hemorrhaging, seizures, shock, and death. Transmission: From monkeys to humans or between humans via Aedes or Haemagogus mosquito vectors. Diagnostic Tests: Culture, serology, PCR. Antimicrobial Drugs: None for treatment; preventive vaccine available."