"163 How Do Club Drugs Affect the Brain? • At high doses, GHB’s sedative effects may result in sleep, coma, or death. • Rohypnol can produce anterograde amnesia, in which individuals may not remember events they experienced while under the influence of the drug. • Ketamine is a dissociative anesthetic, so called because it distorts perceptions of sight and sound and produces feelings of detachment from the environment and self. Low - dose intoxication results in impaired attenti on, learning ability, and memory. At higher doses, ketamine can cause dreamlike states and hallucinations; and at higher doses still, ketamine can cause delirium and amnesia. Addictive Potential Repeated use of GHB may lead to withdrawal effects, including insomnia, anxiety, tremors, and sweating. Severe withdrawal reactions have been reported among patients presenting from an overdose of GHB or related compounds, especially if other drugs or alcohol are involved. • Like other benzodiazepines, chronic use of Rohypnol can produce tolerance, physical dependence, and addiction. • There have been reports of people binging on ketamine, a behavior that is similar to that seen in some cocaine - or amphetamine - dependent individuals. Ketamine users can develop signs of to lerance and cravings for the drug. What Other Adverse Effects Do Club Drugs Have on Health? Uncertainties about the sources, chemicals, and possible contaminants used to manufacture many club drugs make it extremely difficult to determine toxicity and ass ociated medical consequences. Nonetheless, we do know that: • Coma and seizures can occur following use of GHB. Combined use with other drugs such as alcohol can result in nausea and breathing difficulties. GHB has been involved in poisonings, overdoses, da te rapes, and deaths. • Rohypnol may be lethal when mixed with alcohol and/or other CNS depressants. • Ketamine, in high doses, can cause impaired motor function, high blood pressure, and potentially fatal respiratory problems. Methamphetamine Methamphetamin e is a very addictive stimulant drug. It can be smoked, injected, inhaled or taken by mouth. It has many street names, such as speed, meth, and chalk. Methamphetamine hydrochloride, the crystal form inhaled by smoking, is referred to as ice,"