Concept
Il-10 Agonism
Nature / Global conservation area coverage substantially exceeds current estimates
"Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism. A tetravalent nanobody-based myeloid-selective IL-10 receptor agonist recapitulates IL-10’s potent suppression of monocytes, macrophages and dendritic cells while avoiding stimulation of T cells."
Related Ideas
- Myeloid AgonistNature · Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism