Chapter

Next-Generation Treatments

From Future of Cancer Science | AACR Cancer Progress Report 2025 by Sambif

Concepts

1. Immune Reprogramming

   "Recent innovations in CRISPR-based technologies are rapidly advancing toward the clinic, offering tools to correct genetic defects, reprogram immune cells, and remodel the TME (see Tumor Microenviron

2. Gene Editing

   "Researchers are also exploring the potential of CRISPR itself as an anticancer treatment. Base and prime editors provide a way to precisely rewrite faulty DNA without cutting it, offering the potenti

3. Targeted Delivery

   "At the same time, researchers are also developing advanced delivery systems that send CRISPR directly to tumors. For example, researchers have recently developed nanoparticles that cross the blood–br

4. Clinical Testing

   "Although these innovations are highly promising, it is important to note that most CRISPR-based therapies are still in early stages of development. These technologies must undergo rigorous testing in