Concept
Immune Response
Covid research / ARTICLE IN PRESS
"Antibodies produced by plasma cells from the activation of naïve or memory B cells in response to SARS-CoV-2 infection or vaccination are critical for recognizing, neutralizing, and preventing the spread of the virus 4. T-follicular helper (Tfh) cells are critical for promoting the generation of germinal centers, where antibody affinity maturation and memory B and plasma cell production occur 5. In COVID-19-convalescent individuals, the frequency of S protein-specific Tfh cells in circulation was positively correlated with neutralizing antibody titers 6,7."
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