Concept
Regression Models
Association between weight/body mass index and insulin dose requirements in gestational diabetes: a retrospective cohort study | BMJ Open Diabetes Research & Care / Results
"Linear regression models demonstrated significant associations between OGTT fasting glucose, pregnancy weight (model 1) or BMI (model 2), and insulin dose required initially to achieve target, although performance of the model was limited (table 3). Similar associations were seen in models predicting maximum insulin (models 3 and 4; table 3); however, model performance was even lower than in those predicting initial insulin dose required to reach the target. The correlation between fasting and 120-minute OGTT glucose results and initial and peak insulin requirements are shown in online supplemental figures S2–S5.\n\nIn models which compared the strength of variable association with insulin dose requirement via variable standardization (models 5 to 8; table 4), OGTT fasting glucose is the strongest predictor of initial insulin dose requirement, and OGTT fasting glucose, BMI, and pre-pregnancy weight had a similar strength of association with maximum insulin dose requirement. In sensitivity analyses, adjustment for metformin use did not substantially alter the relationships between OGTT glucose values, BMI, and insulin requirements (online supplemental table S1)."
Related Ideas
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- Sensitivity AnalysisAssociation between weight/body mass index and insulin dose requirements in gestational diabetes: a retrospective cohort study | BMJ Open Diabetes Research & Care · Statistical analysis
- Insulin RequirementsAssociation between weight/body mass index and insulin dose requirements in gestational diabetes: a retrospective cohort study | BMJ Open Diabetes Research & Care · Definitions of study outcomes
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- Dose PredictionAssociation between weight/body mass index and insulin dose requirements in gestational diabetes: a retrospective cohort study | BMJ Open Diabetes Research & Care · Comparison with previous literature
- Predictive ModelsAssociation between weight/body mass index and insulin dose requirements in gestational diabetes: a retrospective cohort study | BMJ Open Diabetes Research & Care · Introduction
- Insulin RequirementsAssociation between weight/body mass index and insulin dose requirements in gestational diabetes: a retrospective cohort study | BMJ Open Diabetes Research & Care · What this study adds
- Clinical VariablesAssociation between weight/body mass index and insulin dose requirements in gestational diabetes: a retrospective cohort study | BMJ Open Diabetes Research & Care · Cohort definition and data collection